Fang S, Benjamin SR, Wu L, Rahman MA, Elder KK, Ojo VT, Zhang T, Brooks TA, Tumey LN. Dissecting the Efficacy and Immunogenicity of TLR7 Agonist-Antibody Conjugates through the Lens of Fc Effector Function, Conjugation Strategies, and Linker Cleavability. J Med Chem. 2025 Nov 24. doi: 10.1021/acs.jmedchem.5c01908. Epub ahead of print. PMID: 41277828.
Ojo VT, Bianchi NA, Yi MZ, Chung SH, Gray ME, Rahman MA, Elder KK, Zhang T, Brooks TA, Tumey LN. Legumain-Cleavable Top1i Antibody-Drug Conjugates without Self-Immolative Spacers Demonstrate Potent Antitumor Activity. J Med Chem. 2025 Nov 20. doi: 10.1021/acs.jmedchem.5c02681. Epub ahead of print. PMID: 41267393.
Mullapudi MR, Xu F, Benjamin SR, Leong KJ, Psaras AM, Rahman MA, Zhang T, Brooks TA, Tumey LN. Resin-Supported Site-Specific Antibody Conjugation Method Leads to Antibody-Drug Conjugates with Retained Efficacy and Improved Stability. Bioconjug Chem. 2025 Sep 17;36(9):1956-1969. doi: 10.1021/acs.bioconjchem.5c00224. Epub 2025 Aug 21. PMID: 40839643.
Xiaowei Dong, Tao Zhang, Liangqiao Bian. Binary lipid system-based granules with undissolved drug crystals enhance oral bioavailability by preventing degradation and improving permeability. International Journal of Pharmaceutics, 2025,126295, ISSN 0378-5173, https://doi.org/10.1016/j.ijpharm.2025.126295.
Dong X, Zhang T, Moreno Sanchez HL, Mans JC, Bae SH, Bian L. Enhancing Oral Absorption of an Ester Prodrug by Coating Drug Crystals with Binary Lipid Systems and Evaluating the Influence of Compositions. Pharmaceutics. 2025 Sep 17;17(9):1210. doi: 10.3390/pharmaceutics17091210. PMID: 41012545; PMCID: PMC12473814.
Alaba T. E., Zhang T., Li Y., Ishaq S. L. Steamed broccoli sprouts diet alleviates inflammatory bowel disease by increasing anti-inflammatory, antioxidant, and gut protective metabolites in an ulcerative colitis mouse model. Functional Foods in Health and Disease 2025; 15(5): 272 – 295. DOI: https://doi.org/10.31989/ffhd.v15i5.1603
Kim J, Nichols DA, Zhang T, Faraone SV, Radonjić NV. Managing attention-deficit/hyperactivity disorder in a breastfeeding mother: A case report. Pharmacotherapy. 2025 Jun 19. doi: 10.1002/phar.70035. Epub ahead of print. PMID: 40536085.
Yang Y, Yi B, Zhang T*. The Impact of Substance Use Disorder and Drug Transfer into Breast Milk: Implications for Maternal and Infant Health. Pharmaceutics. 2025; 17(6):719. Published: 29 May 2025. https://doi.org/10.3390/pharmaceutics17060719. *Corresponding author.
Zhao Z, Zou P, Fang Y, Si T, Li Y, Yi B, Zhang T*. Machine learning approaches for assessing medication transfer to human breast milk. J Pharmacokinet Pharmacodyn. 2025 Apr 16;52(3):25. doi: 10.1007/s10928-025-09972-9. PMID: 40240653. *Corresponding author.
Dash SK, Rahman MA, Yi B, Williams B, Lim GS, Zhou S, Zou P, Li Y, Mahler GJ, Zhang T*. Microfluidic blood-milk barrier and physiologically based pharmacokinetic model to predict lofexidine secretion into breast milk. J Pharm Sci. 2025 Mar 19;114(6):103767. doi: 10.1016/j.xphs.2025.103767. Epub ahead of print. PMID: 40113090. *Corresponding author.
Wang, L., Zhang, T*. A Review on the Potential Health Concerns of New Psychoactive Substances on Pregnancy and Lactation: An Overlooked Threat. Curr. Pharmacol. Rep. 11, 11 (2025). https://doi.org/10.1007/s40495-025-00392-4. *Corresponding author.
Qian L, Zhang T, Dinh J, Paine MF, Zhou Z. Physiologically Based Pharmacokinetic Modeling of Cannabidiol, Delta-9-Tetrahydrocannabinol, and Their Metabolites in Healthy Adults After Administration by Multiple Routes. Clin Transl Sci. 2025 Jan;18(1):e70119. doi: 10.1111/cts.70119. PMID: 39748462; PMCID: PMC11695271.
Md. Mofizur Rahman, Jing Wang, Guosheng Wang, Zhipeng Su, Yizeng Li, Yundi Chen, Jinguo Meng, Yao Yao, Lefei Wang, Stephan Wilkens, Jifu Tan, Juntao Luo, Tao Zhang, Chuandong Zhu, Sung Hyun Cho, Lixue Wang, Luke P. Lee, and Yuan Wan. Chimeric nanobody-decorated liposomes by self-assembly. Nat. Nanotechnol. (2024). https://doi.org/10.1038/s41565-024-01620-6
Zhang T, Zou P. Interspecies Scaling of Transgene Products for Viral Vector Gene Therapies: Method Assessment Using Data from Eleven Viral Vectors. AAPS J. 2023 Oct 27;25(6):101. doi: 10.1208/s12248-023-00867-6. PMID: 37891410.
Allesandra Stratigakis, Dylan Paty, Peng Zou, Zhongyuan Zhao, Yanyan Li, Tao Zhang. A regression approach for assessing large molecular drug concentration in breast milk. Reproduction and Breeding, Volume 3, Issue 4, 2023, Pages 199-207, ISSN 2667-0712.https://doi.org/10.1016/j.repbre.2023.10.003.
Holcomb L, Holman JM, Hurd M, Lavoie B, Colucci L, Hunt B, Hunt T, Kinney M, Pathak J, Mawe GM, Moses PL, Perry E, Stratigakis A, Zhang T, Chen G, Ishaq SL, Li Y. Early life exposure to broccoli sprouts confers stronger protection against enterocolitis development in an immunological mouse model of inflammatory bowel disease. mSystems. 2023 Dec 21;8(6):e0068823. doi: 10.1128/msystems.00688-23. Epub 2023 Nov 9. PMID: 37942948; PMCID: PMC10734470.
Holman JM, Colucci L, Baudewyns D, Balkan J, Hunt T, Hunt B, Kinney M, Holcomb L, Stratigakis A, Chen G, Moses PL, Mawe GM, Zhang T, Li Y, Ishaq SL. Steamed broccoli sprouts alleviate DSS-induced inflammation and retain gut microbial biogeography in mice. mSystems. 2023 Sep 13:e0053223. doi: 10.1128/msystems.00532-23. Epub ahead of print. PMID: 37702510.
Zhang T, Holman J, McKinstry D, Trindade BC, Eaton KA, Mendoza-Castrejon J, Ho S, Wells E, Yuan H, Wen B, Sun D, Chen GY, Li Y. A steamed broccoli sprout diet preparation that reduces colitis via the gut microbiota. J Nutr Biochem. 2023 Feb;112:109215. doi: 10.1016/j.jnutbio.2022.109215. Epub 2022 Nov 9. Erratum in: J Nutr Biochem. 2023 Jul;117:109340. PMID: 36370930.
Holman J, Hurd M, Moses PL, Mawe GM, Zhang T, Ishaq SL, Li Y. Interplay of Broccoli/Broccoli Sprout Bioactives with Gut Microbiota in Reducing Inflammation in Inflammatory Bowel Diseases. J Nutr Biochem. 2023 Mar;113:109238. doi: 10.1016/j.jnutbio.2022.109238. Epub 2022 Nov 26. PMID: 36442719; PMCID: PMC9974906.
Yanyan Li, Tao Zhang, Johanna Holman, Delaney McKinstry, Bruno Caetano Trindade, Jonny Mendoza-Castrejon, Sharon Ho, Duxin Sun, Emily Wells, Grace Chen. A specific broccoli sprout preparation reduces chemically-induced colitis via gut microbiota. Current Developments in Nutrition. 2022, 6(S1): 307. https://doi.org/10.1093/cdn/nzac053.048
Zhang T, Zou P, Fang Y, Li Y. Physiologically based pharmacokinetic model to predict drug concentrations of breast cancer resistance protein substrates in milk. Biopharm Drug Dispos. 2022 Oct 20. doi: 10.1002/bdd.2335. Epub ahead of print. PMID: 36265038.
Tao Zhang*, Zachary Applebee, Peng Zou, Zhen Wang, Erika Solano Diaz, Yanyan Li. An in vitro human mammary epithelial cell permeability assay to assess drug secretion into breast milk. Int J Pharm X. 2022 Jun 22;4:100122. doi: 10.1016/j.ijpx.2022.100122. PMID: 35789754; PMCID: PMC9249612. *Corresponding author.
Hong Yang, Ivy Xue, Qimei Gu, Peng Zou, Tao Zhang, Yanhui Lu, Jeffery Fisher, and Doanh Tran. Developing an In Vitro to In Vivo Extrapolation (IVIVE) Model to Predict Human Milk-to-Plasma Drug Concentration Ratios. Molecular Pharmaceutics. 2022 Jun 8. doi: 10.1021/acs.molpharmaceut.2c00193.
Jingcheng Xiao, Jian Shi, Brian R Thompson, David E Smith, Tao Zhang, Hao-Jie Zhu. Physiologically-based pharmacokinetic modeling to predict methylphenidate exposure affected by interplay among carboxylesterase 1 pharmacogenetics, drug-drug interactions, and sex. J Pharm Sci. 2022 May 5;S0022-3549(22)00190-3. doi: 10.1016/j.xphs.2022.04.019.
Agnes Nuo Han, Beatrice Rae Han, Tao Zhang, Tycho Heimbach. Hepatic Impairment Physiologically Based Pharmacokinetic Model Development: Current Challenges. Current Pharmacology Reports. 2021. https://doi.org/10.1007/s40495-021-00266-5
Tao Zhang*, Peng Zou. Assessing Food Effects on Oral Drug Absorption Based on the Degree of Renal Excretion. The AAPS J. 2021 Mar 21;23(3):47. doi: 10.1208/s12248-021-00570-4. *Corresponding author.
Jingcheng Xiao, Doanh Tran, Xinyuan Zhang, Tao Zhang, Shirley Seo, Haojie Zhu, Peng Zou. Biliary Excretion–Mediated Food Effects and Prediction. The AAPS Journal volume 22, Article number: 124 (2020) https://doi.org/10.1208/s12248-020-00509-1.
Emily Wells, Tao Zhang*. A Review of Current Methods for Food Effect Prediction During Drug Development. Current Pharmacology Reports 6, 267-279, September 02, 2020. https://doi.org/10.1007/s40495-020-00230-9. *Corresponding author.
Courtney Perry, Grace Davis, Todd M. Conner, Tao Zhang*. Utilization of Physiologically Based Pharmacokinetic Modeling in Clinical Pharmacology and Therapeutics: an Overview. Current Pharmacology Reports (2020). 12 May 2020. doi: https://doi.org/10.1007/s40495-020-00212-x. *Corresponding author.
Todd M. Conner, Ronald C. Reed, Tao Zhang*. A Physiologically-Based Pharmacokinetic Model For Optimally Profiling Lamotrigine Disposition and Drug-drug Interactions. European Journal of Drug Metabolism and Pharmacokinetics. 2019 Jun; 44(3): 389-408. doi: 10.1007/s13318-018-0532-4. *Corresponding author.
Yanyan Li, Tao Zhang, Grace Y. Chen. Flavonoids and Colorectal Cancer Prevention: A Systematic Review. Antioxidants. 2018, 7(12), 187; https://doi.org/10.3390/antiox7120187.
Yanyan Li, Yeon Bai, Bo Wen, Tao Zhang. Comparison of Sulforaphane Content: Traditional vs. Modified Kimchi Recipes. Journal of The Academy of Nutrition and Dietetics. Sep 2018. Volume 118, Issue 9, Supplement.
Yanyan Li, Aaron Domina, Gi Lim, Teralyn Chang, Tao Zhang. Evaluation of curcumin, a natural product in turmeric, on Burkitt lymphoma and acute myeloid leukemia cancer stem cell markers. Future Oncol. 2018 Oct;14(23):2353-2360. doi: 10.2217/fon-2018-0202.
Todd M. Conner, Vahagn C. Nikolian, Patrick E. Georgoff, Manjunath P. Pai, Hasan B Alam, Duxin Sun, Ronald C. Reed, Tao Zhang*. Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for valproic acid and divalproex. Eur J Pharm Sci. 2018 Jan 1;111:465-481. doi: 10.1016/j.ejps.2017.10.009. Epub 2017 Oct 10.*Corresponding author.
Joseph P. Burnett, Gi Lim, Yanyan Li, Ronak B. Shah, Rebekah Lim, Hayley J. Paholak, Sean P. McDermott, Lichao Sun, Yasuhiro Tsume, Shuhua Bai, Max S. Wicha, Duxin Sun, Tao Zhang*. Sulforaphane Enhances the Anticancer Activity of Taxanes against Triple Negative Breast Cancer by Killing Cancer Stem Cells. Cancer Letters. 2017 Feb 27. http://dx.doi.org/10.1016/j.canlet.2017.02.023 *Corresponding author.
Yanyan Li, Katharine Atkinson, Tao Zhang. Combination of chemotherapy and cancer stem cell targeting agents: Preclinical and clinical studies. Cancer Letters. 2017 Mar 12;396:103-109. doi: 10.1016/j.canlet.2017.03.008.
Wenpeng Zhang, Yanyan Li, Peng Zou, Man Wu, Zhenqing Zhang, Tao Zhang*. The Effects of Pharmaceutical Excipients on Gastrointestinal Tract Metabolic Enzymes and Transporters – an Update. The AAPS Journal. 2016 May 16. DOI: 10.1208/s12248-016-9928-8. *Corresponding author.
Tao Zhang*. Physiologically Based Pharmacokinetic Modeling of Disposition and Drug-Drug Interactions for Atorvastatin and its Metabolites. Eur J Pharm Sci. 2015 Jun 24; 77:216-229. *Corresponding author
Tao Zhang, Tycho Heimbach, Wen Lin, Jin Zhang, Handan He. Prospective Predictions of Human Pharmacokinetics for Eighteen Compounds. Journal of Pharmaceutical Sciences, 2015 Sep;104(9):2795-806. doi: 10.1002/jps.24373. Epub 2015 Feb 17.Selected for inclusion in the Gordon L. Amidon Dedicated Issue.
Binfeng Xia, Avantika Barve, Tycho Heimbach, Tao Zhang, Helen Gu, Lai Wang, Heidi Einolf, Natalya Alexander, Imad Hanna, June Ke, James B Mangold, Handan He, Gangadhar Sunkara. Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir. Eur J Pharm Sci. 2014 Oct 15;63:103-12. doi: 10.1016/j.ejps.2014.06.021. Epub 2014 Jul 4.
Yanyan Li, Tao Zhang. Targeting of cancer stem cells by curcumin and clinical applications. Cancer Letters, 2014 May 1;346(2):197-205. doi: 10.1016/j.canlet.2014.01.012. Epub 2014 Jan 23.
Fardokht Abulwerdi, Chenzhong Liao, Meilan Liu, Asfar S. Azmi, Amro Aboukameel, Ahmed S.A. Mady,Thippeswamy Gulappa, Tomasz Cierpicki, Scott Owens, Tao Zhang, Duxin Sun, Jeanne A. Stuckey, Ramzi M. Mohammad, and Zaneta Nikolovska-Coleska. A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In vitro and In vivo. Molecular Cancer Therapeutics, 2014 Mar; 13 (3): 565-75.
Kathy M Soriano, Yanyan Li, Tao Zhang (2014) African American Females: A Potential Link Between Vitamin D Insufficiency and Type-2 Diabetes. J Nutr Health Food Eng 1(3): 00015.
Tao Zhang, Yanyan Li, Peng Zou, Jing-yu Yu, Donna McEachern, Shaomeng Wang, Duxin Sun. Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling of an Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in a Mouse Xenograft Model of Human Breast Cancer. Biopharm Drug Dispos 2013 Sep; 34(6): 348-59.
Yanyan Li, Tao Zhang, Xiaoqin Li, Peng Zou, Steven J. Schwartz, Duxin Sun. Kinetics of Sulforaphane in Mice after Consumption of Sulforaphane-Enriched Broccoli Sprout Preparation. Molecular Nutrition & Food Research 2013 Dec; 57(12):2128-36.
Yanyan Li, Tao Zhang, Xiaoqin Li, Peng Zou, Steven J. Schwartz, Duxin Sun. Kinetics of Sulforaphane in Mice after Consumption of Sulforaphane-Enriched Broccoli Sprout Preparation. Molecular Nutrition & Food Research 2013 Dec; 57(12):2128-36.
Yanyan Li, Tao Zhang. Targeting Cancer Stem Cells by Sulforaphane, a Dietary Component from Broccoli and Broccoli Sprouts. Future Oncology 2013 Aug; 9(8):1097-103.
Yanyan Li, G. Elif Karagoz, Young Ho Seo, Tao Zhang, Yiqun Jiang, Yanke Yu, Steven J. Schwartz, Kate Carroll, Stefan Rudiger, and Duxin Sun. Sulforaphane inhibits Hsp90 function by disrupting Hsp90-Cdc37 complex in pancreatic cancer cells through direct interaction with specific residues. J Nutr Biochem, 2012 Dec; 23(12):1617-26.
Yanyan Li, Tao Zhang, Steven J. Schwartz, and Duxin Sun. Sulforaphane potentiates the therapeutic efficacy of 17-AAG against pancreatic cancer by enhancing 17-AAG-induced abrogation of Hsp90 chaperone function. Nutrition and Cancer, 2011; 63 (7):1151-9.
Tao Zhang, Yanyan Li, Zhenkun Zhu, Mancang Gu, Bryan Newman, Duxin Sun. MEK inhibition potentiates the activity of Hsp90 inhibitor 17-AAG against pancreatic cancer cells. Molecular Pharmaceutics, 2010; 7(5): 1576–1584.
Yanyan Li, Tao Zhang, Hasan Korkaya, Suling Liu, Hsiu-Fang Lee, Bryan Newman, Yanke Yu, Shawn G. Clouthier, Steven J. Schwartz, Max S. Wicha, and Duxin Sun. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res, 2010; 16(9): 2580-90.
Yiqun Jiang, Denzil Bernard, Yanke Yu, Yehua Xie, Tao Zhang, Yanyan Li, Xueqi Fu, Shaomeng Wang, and Duxin Sun. Split Renilla Luciferase Protein Fragment-assisted Complementation (SRL-PFAC) to Characterize Hsp90-Cdc37 Complex and Identify Critical Residues in Protein/Protein Interactions. J Biol Chem, 2010; 285(27): 21023–21036.
Yanke Yu, Adel Hamza, Tao Zhang, Mancang Gu, Peng Zou, Bryan Newman, Yanyan Li, A.A. Leslie Gunatilaka, Chang-Guo Zhan, and Duxin Sun. Withaferin A targets heat shock protein 90 in pancreatic cancer cells. Biochem Pharmacol, 2010; 79(4): 542-51.
Justine L. Lam, Ying Jiang, Tao Zhang, Eric Y. Zhang and Bill J. Smith. Expression and Functional Analysis of Hepatic Cytochrome P450s, Nuclear Receptors and Membrane Transporters in 10-week and 25-week old db/db Mice. Drug Metab Dispos, 2010; 38(12): 2252-58.
Tao Zhang, Yanyan Li, Yanke Yu, Peng Zou, Yiqun Jiang, and Duxin Sun. Characterization of celastrol to inhibit Hsp90 and Cdc37 interaction. J Biol Chem, 2009; 284(51): 35381-9.
Yanyan Li*, Tao Zhang*, Yiqun Jiang, Hsiu-Fang Lee, Steven J. Schwartz and Duxin Sun. (-)-Epigallocatechin-3-gallate Inhibits Hsp90 Function by Impairing Hsp90 Association with Cochaperones in Pancreatic Cancer Cell Line Mia Paca-2. Molecular Pharmaceutics, 2009 Jul-Aug; 6(4):1152-9. *equal authorship
Yanyan Li*, Tao Zhang*, Steven J. Schwartz and Duxin Sun. New developments in Hsp90 inhibitors as anti-cancer therapeutics: Mechanisms, clinical perspective and more potential. Drug Resistance Updates, 2009; 12(1): 17-27. *equal authorship
Tao Zhang, Adel Hamza, Xianhua Cao, Bing Wang, Shuwen Yu, Chang-Guo Zhan and Duxin Sun. A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Molecular Cancer Therapeutics, 2008 7: 162-170
Tao Zhang, Cathie D. Xiang, David Gale, Samantha Carreiro, Ellen Y. Wu, and Eric Y. Zhang. Drug Transporter and Cytochrome P450 mRNA Expression in Human Ocular Barriers: Implications for Ocular Drug Disposition. Drug Metab Dispos, 2008; 36(7):1300-7.
Xianhua Cao, Mark Bloomston, Tao Zhang, Wendy L. Frankel, Guang Jia, Bing Wang, Nathan C. Hall, Regina M. Koch, Hao Cheng, Michael V. Knopp and Duxin Sun. Synergistic Antipancreatic Tumor Effect by Simultaneously Targeting Hypoxic Cancer Cells with HSP90 Inhibitor and Glycolysis Inhibitor. Clin Cancer Res, 2008 Mar 15;14(6):1831-9.
Xianhua Cao, Guang Jia, Tao Zhang, Ming Yang, Bing Wang, Peter A. Wassenaar, Hao Cheng, Michael V. Knopp and Duxin Sun. Non-invasive MRI tumor imaging and synergistic anticancer effect of HSP90 inhibitor and glycolysis inhibitor in RIP1-Tag2 transgenic pancreatic tumor model. Cancer Chemother Pharmacol, 2008 Nov;62(6):985-94.
Huifei Cui, Jie Shen, Dongning Lu, Tao Zhang, Wenpeng Zhang, Duxin Sun and Peng George Wang. 4-Aryl-1,3,2-oxathiazolylium-5-olate: a novel GST inhibitor to release JNK and activate c-Jun for cancer therapy. Cancer Chemother Pharmacol, 2008 Aug;62(3):509-15.
Huifei Cui, Jie Shen, Dongning Lu, Tao Zhang, Wenpeng Zhang, Duxin Sun and Peng George Wang. 4-Aryl-1,3,2-oxathiazolylium-5-olate: a novel GST inhibitor to release JNK and activate c-Jun for cancer therapy. Cancer Chemother Pharmacol, 2008 Aug;62(3):509-15.
Di Guo, Xiaorong Gao , Hao Li, Tao Zhang, Lijia An and Ning LI. EGY1 plays a role in regulation of endodermal plastid size and number that are involved in ethylene-dependent gravitropism of light-grown Arabidopsis hypocotyls. Plant Molecular Biology, 2008; 66, 345-360.
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